E1: A disposable bioreactor for culturing microorganisms or cells, comprising flexible or semi-flexible waterproof sheets sealed along their edges to form a container.

E2: The container having a wedge shaped or rounded bottom, at the lowermost extremity of which is positioned a gas bubbler for generating gas bubbles for mixing and providing gases to microbial or cellular liquid cultures within the container.

E3: The container further comprising at least one inlet port for introducing gases or liquids and at least one exit port for exhausting gases or removing liquids wherein the exit port further comprises a coiled exhaust tube extending therefrom.